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The Dystonia Medical Research Foundation (DMRF) has stood up for the dystonia community since 1976. Join us in our global effort to find a cure.

Dystonia News

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September is Dystonia Awareness Month

An estimated 250,000 people in the United States have dystonia, a chronic movement disorder affecting the brain and nervous system. It is the third most common movement disorder after essential tremor and Parkinson disease. Dystonia causes excessive, uncontrollable muscle spasms. The muscle spasms twist the body and limbs into involuntary movements and awkward postures. Estimates […]

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Survey: Dystonia & Mental Health

The Dystonia & Speech Motor Control Lab at Massachusetts Eye and Ear Infirmary is conducting an online survey examining psychological co-morbidities in patients with dystonia. The survey is open to anyone diagnosed with any form of dystonia, and takes approximately 10-15 minutes to complete. Click here for detailed information about the survey, and to participate. […]

Dystonia Events

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Providence Zoo Walk

September 14, 2019

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Cincinnati Zoo Walk

September 21, 2019

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Philadelphia Zoo Walk

September 22, 2019

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Toledo Zoo Walk

October 5, 2019

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Current Dystonia Research Investigations

The Dystonia Medical Research Foundation (DMRF) prides itself on a long history of supporting and stimulating dystonia research.
Striatal Neuron Activity Patterns in Dystonia

The causes of dystonia are not clearly understood but abnormal signaling within the striatum, a region of the brain that controls movement, is thought to be involved. It is now possible to record the firing patterns of dozens of neurons simultaneously in the striatum of awake dystonic mice to reveal the abnormal neural code associated with dystonia. Technology known as in vivo microscopy will be used in mice with dystonia to visualize the firing patterns of neurons within the striatum. Mice will be recorded while they are dystonic and after they have been treated with drugs that alleviate the dystonia. By comparing the different firing patterns with and without dystonia, these experiments will reveal the neural code associated with dystonia for the first time. In the short term, these experiments will provide important information that could be useful to guide stimulation parameters for deep brain stimulation in dystonia patients. In the long-term, understanding the neural code of dystonia will provide important information for the development of novel therapeutics that target the abnormal neural code.

Ellen Hess, PhD Emory University (USA)

Machine Learning Guided Deep Brain Stimulation to Cure Neurological Disease

The DMRF is partnering with Jesse H. Goldberg, MD, PhD of Cornell University on a project to engineer a revolutionary new generation of deep brain stimulation (DBS) devices to treat dystonia and other neurological diseases.

Dystonia results from abnormal brain activity that can be corrected by direct electrical stimulation of dysfunctional brain pathways. In current DBS systems, an implanted medical device delivers continuous stimulation to the brain and adjustments to the stimulation must be made using a remote control device in the hands of a highly trained clinician. A major obstacle to providing patients with maximum benefit from this therapy is knowing where in the brain to stimulate and tailoring stimulation parameters to the unique needs of each patient.

Dr. Goldberg proposes a radically new approach to DBS. He is using artificial intelligence to develop a system in which a computer, interconnected with the brain, figures out exactly how and where to stimulate to restore normal movement.

In this three-year project, Dr. Goldberg will establish the feasibility of this concept in mice. He is collaborating with Mert Sabuncu, PhD in the School of Electrical and Computer Engineering and School of Biomedical Engineering at Cornell University.

Jesse H. Goldberg, MD, PhD Cornell University (USA)

Three-Dimensional Network Architecture of Dystonia

Brain imaging techniques have advanced the understanding of metabolic network abnormalities in inherited and sporadic dystonia. It remains elusive, however, whether dystonia-related brain networks can be identified with resting state functional MRI (magnetic resonance imaging) utilizing time-series information. It is also unclear whether such networks relate to underlying anatomical connections. Dr. Vo hypothesizes that dystonia is characterized by distinct functional and structural network topographies in the resting state. To test this hypothesis, she and her team will examine resting state functional MRI and diffusion MRI data in patients with inherited and sporadic dystonia. The proposed work will advance the understanding of brain network architecture in dystonia. The new information will help identify areas within the network space for optimal therapeutic targeting and individually customized treatment.

An Vo, PhD The Feinstein Institute for Medical Research (USA)
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